The Quantum Science Center (QSC) is working to create the first fault-tolerant ecosystem for hybrid quantum high-performance computing (QHPC). By uniting national laboratories, academic institutions, and industry partners, the QSC seeks to develop a holistic software ecosystem that combines research in hybrid algorithms, scientific applications, QHPC architectures, and experimental validation that amplifies the impact of fault-tolerant quantum computing. Its efforts will help to position the United States at the forefront of quantum-accelerated computing, benefiting science and technology globally.